Dynamic phenotypes as criteria for model discrimination: fold-change detection in R. sphaeroides
نویسندگان
چکیده
The chemotaxis pathway of the bacterium Rhodobacter sphaeroides has many similarities to the well-studied pathway in Escherichia coli. It exhibits robust adaptation and has several homologues of the latter’s chemotaxis proteins. Recent theoretical results have been able to correctly predict that the chemotactic response of Escherichia coli exhibits the same output behavior in response to scaled ligand inputs, a dynamic property known as fold-change detection (FCD), or input-scale invariance. In this paper, we present theoretical assumptions on the R. sphaeroides chemotaxis sensing dynamics that can be analytically shown to yield FCD behavior in a specific ligand concentration range. Based on these assumptions, we construct two models of the full chemotaxis pathway that are able to reproduce experimental time-series data from earlier studies. To test the validity of our assumptions, we propose a series of experiments in which our models predict robust FCD behavior where earlier models do not. In this way, we illustrate how a dynamic phenotype such as FCD can be used for the purposes of discriminating between two models that reproduce the same experimental time-series data.
منابع مشابه
Transient dynamic phenotypes as criteria for model discrimination: fold-change detection in Rhodobacter sphaeroides chemotaxis
The chemotaxis pathway of the bacterium Rhodobacter sphaeroides shares many similarities with that of Escherichia coli. It exhibits robust adaptation and has several homologues of the latter's chemotaxis proteins. Recent theoretical results have correctly predicted that the E. coli output behaviour is unchanged under scaling of its ligand input signal; this property is known as fold-change dete...
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